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Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors.t8 A * 7   .Clonal Selection Theory (F. Macfarlane Burnet)/ / pre-existence of of many different potential antibody producing cells each cell displays surface receptors for specific antigens antigen encounter selects cells What prevents recognition/destruction of self tissues?b# 5 >   -Postulates of the Clonal Selection Hypothesis . 3Each lymphocyte bears a single type of receptor of a unique specificity Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity to those of the parental cell from which that lymphocyte was derived Lymphocytes bearing receptors specific for self molecules are deleted at an early stage in lymphocyte development and are therefore absent from the repertoire45CZ 4  )Diversity of Lymphocyte Antigen Receptors * Variable region of antigen receptor encoded by sets of gene segments During lymphocyte development somatic gene rearrangement create unique combinations of gene segments Once recombinant events have occurred, further rearrangement is prohibited Receptor specificity of a lymphocyte cannot change Each lymphocyte bears many copies of the unique receptor At least 108 different lymphocytes in an individual( R & !(   7Genomic Organization of heavy- and light-chain segments 8   &Development of the Antibody Repertoire ' The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) Diversity is enhanced by hypermutation in mature B cells (germline theory)H<@       ESome Comments on Cluster of Differentiation/Designation (CD) AntigensFF( F What are they? Differentiation antigens Expressed by cells at distinct stages of differentiation Expressed by cells having different functions How are they detected?6  *Fluorescence-Activated Cell Sorting (FACS)++$ +   Lymphocyte Populations  NB lymphocytes Plasma cells T lymphocytes Helper/Inducer (CD4) Suppressor (CD8)&)&)& O  T Cell Recognition of Antigen  sRecognize antigen peptide fragments bound to specialize cell surface molecules on antigen-presenting cells (APC). Molecules are encoded by major histocompatibility complex Peptides are displayed to T cells as peptide:MHC complexes T cell antigen receptors recognize peptide:MHC complexes Each MHC molecule can bind numerous different peptides Two classes of MHC moleculest 2 &    4Major Histocompatibility Complex (MHC) Gene Products55(&   >Class I Antigen is usually endogenous (e.g. viral proteins). CD8+ Cytotoxic T Lymphocytes (CTLs) recognize antigen in association with class I MHC gene product on APC. Class II Molecules Antigen is usually extracellular. CD4+ Helper T Lymphocytes recognize antigen in association with class II MHC gene product on APC. g ^&[    ,Cellular Cooperation and Antigen Recognition -   B Cell Antigen Recognition  Cell surface immunoglobulin receptor or B-cell receptor (IgM and IgD) Antigen contact initiates B-cell activation, clonal expansion, maturation to plasma cell Antigen receptor is identical to immunoglobulin that will ultimately be produced\ )^ 4@A  /  w Cellular Cooperation   ,Clonal Expansion Following Antigen Exposure --$ -  The Bottom Line  In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors. 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Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors.t8 A * 7  .Clonal Selection Theory (F. Macfarlane Burnet)/ /pre-existence of of many different potential antibody producing cells each cell displays surface receptors for specific antigens antigen encounter selects cells What prevents recognition/destruction of self tissues?b# 5 >  -Postulates of the Clonal Selection Hypothesis .3Each lymphocyte bears a single type of receptor of a unique specificity Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity to those of the parental cell from which that lymphocyte was derived Lymphocytes bearing receptors specific for self molecules are deleted at an early stage in lymphocyte development and are therefore absent from the repertoire45CZ 4 )Diversity of Lymphocyte Antigen Receptors *Variable region of antigen receptor encoded by sets of gene segments During lymphocyte development somatic gene rearrangement create unique combinations of gene segments Once recombinant events have occurred, further rearrangement is prohibited Receptor specificity of a lymphocyte cannot change Each lymphocyte bears many copies of the unique receptor At least 108 different lymphocytes in an individual( R & !(  7Genomic Organization of heavy- and light-chain segments 8  &Development of the Antibody Repertoire 'The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) Diversity is enhanced by hypermutation in mature B cells (germline theory)H<2  ESome Comments on Cluster of Differentiation/Designation (CD) AntigensFF( FWhat are they? Differentiation antigens Expressed by cells at distinct stages of differentiation Expressed by cells having different functions How are they detected?6 *Fluorescence-Activated Cell Sorting (FACS)++$ +  Lymphocyte Populations NB lymphocytes Plasma cells T lymphocytes Helper/Inducer (CD4) Suppressor (CD8)&)&)& O T Cell Recognition of Antigen sRecognize antigen peptide fragments bound to specialize cell surface molecules on antigen-presenting cells (APC). Molecules are encoded by major histocompatibility complex Peptides are displayed to T cells as peptide:MHC complexes T cell antigen receptors recognize peptide:MHC complexes Each MHC molecule can bind numerous different peptides Two classes of MHC moleculest 2  4Major Histocompatibility Complex (MHC) Gene Products55(>Class I Antigen is usually endogenous (e.g. viral proteins). CD8+ Cytotoxic T Lymphocytes (CTLs) recognize antigen in association with class I MHC gene product on APC. Class II Molecules Antigen is usually extracellular. CD4+ Helper T Lymphocytes recognize antigen in association with class II MHC gene product on APC. g ^[ ,Cellular Cooperation and Antigen Recognition -  B Cell Antigen Recognition Cell surface immunoglobulin receptor or B-cell receptor (IgM and IgD) Antigen contact initiates B-cell activation, clonal expansion, maturation to plasma cell Antigen receptor is identical to immunoglobulin that will ultimately be produced\ )^ 42A/wCellular Cooperation  ,Clonal Expansion Following Antigen Exposure --$ - The Bottom Line In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors. 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%Lecture 4 Antigen Recognition(  Overview In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors.t8 A * 7  .Clonal Selection Theory (F. Macfarlane Burnet)/ /pre-existence of of many different potential antibody producing cells each cell displays surface receptors for specific antigens antigen encounter selects cells What prevents recognition/destruction of self tissues?b# 5 >  -Postulates of the Clonal Selection Hypothesis .3Each lymphocyte bears a single type of receptor of a unique specificity Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity to those of the parental cell from which that lymphocyte was derived Lymphocytes bearing receptors specific for self molecules are deleted at an early stage in lymphocyte development and are therefore absent from the repertoire45CZ 4 )Diversity of Lymphocyte Antigen Receptors *Variable region of antigen receptor encoded by sets of gene segments During lymphocyte development somatic gene rearrangement create unique combinations of gene segments Once recombinant events have occurred, further rearrangement is prohibited Receptor specificity of a lymphocyte cannot change Each lymphocyte bears many copies of the unique receptor At least 108 different lymphocytes in an individual( R & !(  7Genomic Organization of heavy- and light-chain segments 8  &Development of the Antibody Repertoire 'The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) Diversity is enhanced by hypermutation in mature B cells (germline theory)H<2  ESome Comments on Cluster of Differentiation/Designation (CD) AntigensFF( FWhat are they? Differentiation antigens Expressed by cells at distinct stages of differentiation Expressed by cells having different functions How are they detected?6 *Fluorescence-Activated Cell Sorting (FACS)++$ +  Lymphocyte Populations NB lymphocytes Plasma cells T lymphocytes Helper/Inducer (CD4) Suppressor (CD8)&)&)& O T Cell Recognition of Antigen sRecognize antigen peptide fragments bound to specialize cell surface molecules on antigen-presenting cells (APC). Molecules are encoded by major histocompatibility complex Peptides are displayed to T cells as peptide:MHC complexes T cell antigen receptors recognize peptide:MHC complexes Each MHC molecule can bind numerous different peptides Two classes of MHC moleculest 2  4Major Histocompatibility Complex (MHC) Gene Products55(>Class I Antigen is usually endogenous (e.g. viral proteins). CD8+ Cytotoxic T Lymphocytes (CTLs) recognize antigen in association with class I MHC gene product on APC. Class II Molecules Antigen is usually extracellular. CD4+ Helper T Lymphocytes recognize antigen in association with class II MHC gene product on APC. g ^[ ,Cellular Cooperation and Antigen Recognition -  B Cell Antigen Recognition Cell surface immunoglobulin receptor or B-cell receptor (IgM and IgD) Antigen contact initiates B-cell activation, clonal expansion, maturation to plasma cell Antigen receptor is identical to immunoglobulin that will ultimately be produced\ )^ 42A/wCellular Cooperation ,Clonal Expansion Following Antigen Exposure --$ - The Bottom Line In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors. 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KH p 0޽h ? a(rA Ej2 hA\((P   2Microsoft ClipArt Gallery $MS_ClipArt_Gallery02Microsoft ClipArt Gallery2Microsoft ClipArt Gallery $MS_ClipArt_Gallery02Microsoft ClipArt Gallery/ 0DTimesGarde߳zz V R0K RDTahomaarde߳zz V R0K R" DArialarde߳zz V R0K R"0DWingdingse߳zz V R0K R@DHelveticae߳zz V R0K R"PDAvant Garde߳zz V R0K Rc0.@  @@``  @n?" dd@  @@`` t1y     BwQ]`b$TNҋЇ{`{b$-TèW#C{r$xQFoJl/Ii8r$m>_z6;+i'9r$ h>"f[gi 9B$8"zGS~v#<B$&~ب3ڌZR$.Kb|Mm# lAA1?0 Q@8+ g4UdUdR 0dPߺRppp ʚ;ʚ;<4ddddS ʚ;ʚ;<4!d!dS ʚ;ʚ;<4BdBdS ʚ;ʚ;0___PPT10 h___PPT2001D<4X0? %Lecture 15 Antigen Recognition(  Overview In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors.t8 A * 7  .Clonal Selection Theory (F. Macfarlane Burnet)/ /pre-existence of of many different potential antibody producing cells each cell displays surface receptors for specific antigens antigen encounter selects cells What prevents recognition/destruction of self tissues?b# 5 >  -Postulates of the Clonal Selection Hypothesis .3Each lymphocyte bears a single type of receptor of a unique specificity Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity to those of the parental cell from which that lymphocyte was derived Lymphocytes bearing receptors specific for self molecules are deleted at an early stage in lymphocyte development and are therefore absent from the repertoire45CZ 4 )Diversity of Lymphocyte Antigen Receptors *Variable region of antigen receptor encoded by sets of gene segments During lymphocyte development somatic gene rearrangement create unique combinations of gene segments Once recombinant events have occurred, further rearrangement is prohibited Receptor specificity of a lymphocyte cannot change Each lymphocyte bears many copies of the unique receptor At least 108 different lymphocytes in an individual( R & !(  7Genomic Organization of heavy- and light-chain segments 8  &Development of the Antibody Repertoire 'The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) Diversity is enhanced by hypermutation in mature B cells (germline theory)H<2  ESome Comments on Cluster of Differentiation/Designation (CD) AntigensFF( FWhat are they? Differentiation antigens Expressed by cells at distinct stages of differentiation Expressed by cells having different functions How are they detected?6 *Fluorescence-Activated Cell Sorting (FACS)++$ +  Lymphocyte Populations NB lymphocytes Plasma cells T lymphocytes Helper/Inducer (CD4) Suppressor (CD8)&)&)& O T Cell Recognition of Antigen sRecognize antigen peptide fragments bound to specialize cell surface molecules on antigen-presenting cells (APC). Molecules are encoded by major histocompatibility complex Peptides are displayed to T cells as peptide:MHC complexes T cell antigen receptors recognize peptide:MHC complexes Each MHC molecule can bind numerous different peptides Two classes of MHC moleculest 2  4Major Histocompatibility Complex (MHC) Gene Products55(>Class I Antigen is usually endogenous (e.g. viral proteins). CD8+ Cytotoxic T Lymphocytes (CTLs) recognize antigen in association with class I MHC gene product on APC. Class II Molecules Antigen is usually extracellular. CD4+ Helper T Lymphocytes recognize antigen in association with class II MHC gene product on APC. g ^[ ,Cellular Cooperation and Antigen Recognition -  B Cell Antigen Recognition Cell surface immunoglobulin receptor or B-cell receptor (IgM and IgD) Antigen contact initiates B-cell activation, clonal expansion, maturation to plasma cell Antigen receptor is identical to immunoglobulin that will ultimately be produced\ )^ 42A/wCellular Cooperation ,Clonal Expansion Following Antigen Exposure --$ - The Bottom Line In order to initiate an immune response antigen must be recognized. Antigen recognition depends on detection of antigen by special receptors. Antigen recognition depends on cellular cooperation. Cellular cooperation is controlled by recognition of MHC-encoded receptors. Antigen  drives the process resulting in  effector cells and  memory cells.^8 A !7?   ^/8PD j @l(    C xmճmճ1 ?d   `  c $A ??`c{ H  0f޽h ? >gԟrV2 x