ࡱ> HNPQRSIn:u3b⺂VBPNG  IHDRkYĒ*gAMAPLTE **QQ **QQ **QQ *QK pHYs   IDATxw.$"IH -=ιrw+Z w֙NJ? sh8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TK蜟NENDP"lJ{޶NakDnG&l Šض [Csy1H_dlۅ@^el[^fkۄ!1mа'[CXcl[ᡭ1džN\=>l i>l Oc{d 54H% m:lakXz~ҥȅ=.l Kw#Ҵ..R=6l-Iu>fk [szlegk [ åNsCy<գւck[S< D}ak^J@bk[3)7γ{ kɔFs- k56.L>Úcck ;QrOLM*SuN7°ZlR''OK³&  [wV+[ɂbkuNs!=AcxEl8==8>5٩Dc 1vaZW{s.NXۮ@56]%Kl5[gAڡ]:l>f} k7;<昭ut7ea[vf΢'.[a:5sj~acf-i]j7l̰{ Dێ K5[FrT]bs>Z.R\h4oyOcv~NX?W"Ft)-&Cl.6嬍E:' [ _2 m+?H2l-|ʋ;n3[ǫ+\铆/_Q޶ۗVڞLyj_:M6S.e5%lV=&ږ.]Bln'3Èd$lkiɶVIZR)2öV(IZBUZ(/6JyjlfQvw]&17n4FcyġV#tTv\Df+ՙS; kU 0rډ{6'ڍNx~bM_mle֞5p:~/~klpsE钭Flp=lsNZZۉ&N 9%֙6KU4aLЭ2D% p?΃)e/2ŧA2TbK2 pe֞+}x&Mq ;ʳf[ [6 c鶚rͫ=kM`+3ElN[ 7,:_ WdJAGն~JEKV[{ Mr ?0KTa(c{45Wȵv: LfES)q^iFX hvb}cyt氕ȵv}X,Aܚ& qʂ=x^X 6f򟙭=OdT)mmLᖵ9 d $,Zt~ߦBjMpc6oQUeI2468&e΢݋mņ_S9Tk^3TM^JV9V(M&6(i-S6juvFH[{Ņ74RϿQ4Rl|zSkE !hjTW-iBGE*3k5[=*~۲k0lZ[hHM6~ݘjkNӷܽ{2]`0׍&[S? 6K-elhè7O[pgY?%Zj;zʥ_~Rm{NjΠjyЖQr}suXLmŶ1Rgki|= [`HMv)pk[Cu&(^qY?Zk' _TDŽh&z(!Tw`kQنAsNԲY4LZ%3W\Xz8xZaeZ;cμI̗S`2>{jkͧXZ/ukN[ƚؠץIe-vuu%izQk7#mm/Rk^ V/|Vj02BMc#+(4~ DZ)EfF67!a摴Vךff3Wʝ[|ۿ RkF.Mk{z4xBpJ3vsS)🀭FؒEZgm_YS m6ZkF7>8ӣ$vuuܡ6ֶM]%23Sk q EFZ $S&'`FilCyct|3c3Ԛw _COS>-c׆BS jߞIqP/&1kX; Ͷ:m|t y5m^䛮85~1tvl=,7KSCSjkO` ­J،FjM.a(~s%u³15bLI#rs$F&a'.h.ևTGEu$~s oasG;E^]vc ZC47ŻKx"Gf(wnتM"[CYkFj\ +jW(4/6 æ?4jR7A9~֨K/HBj _+~$NemM[K_l4;-HRar߯,39s]v2FVIx;GP~Y|faPhpOU=l =TҚfj+M5Ja(k29k:!`騿ipn.1i`o(4]cEϳ>o|R9ktZa V},;зMPi(oZsSjg-}ʖkTJLZԬ5ܩ_a4-\m܅A@RaԳ9]-:m=Δ7SB٪_ʚ/M&ykŶ֚Z_Sa.k$tݘ{(U{C`t/guBlbKkAe@G -7`%Z?H\:mJk^ ݓZct#s) "kmӽE%KǭPk5VokxYA6H#~U/ؐmjɚ7#륻=[#6Z";pn{ְUĆR3OpQ?WYO9N7B8zP,sտ=>W^TĚ|O:liYV!_6Imdo13c/}[)F)5Cɇ$̻l`Wk[ڻ_fG3&G"[([vۘ55cC[;k m}5@LF|vLw!I60!}XkFlw ZeĞOscl_Nr4f&&ǀZm 5FOt2؈Pk!vqlAXƚz,md k۠Ys+""$uc+l$x(ךؽ'̝oxp"tp˓\LWZ΢.{\\a-K2ƿ,6֢ﻲZmu\ X0jIR9h_^l4|aOZs-+$u>\@VjLtRlft,7gOPYKuљMoo!6n>ϑZZivc2mjJrůXK.lݎ-F1GQO$rtVZ#M&SԢ+aTʶlfԜr>.IO3 'N]ٯ0DMnٸf*vӂ Ö.#9 ~a3@w5HjHn+sfؚʏkE |k-FNTw/~]]m۝tJn1)6pF$6#f)٢Uckb6\t$;GT46l!ϓz[kHnl$(\6sP=5斬 jq˼ ޒ_r䯤5yȟ2[Sje o-pM:&l- Zm5ǍZ(bC1Dl^pya 6t5qއӥGcMs#AQ|nYlő0Y3*bC/WVw]5D9mJ^MJ `Q dt<;+/el[t?P`K?39 .3ب vP`K 6|6t>RW`0`Ksʹ[O B:tbSgQOئ*vΒrt؈k $n 6dô:aCU-|g؈Mp8{M[bWz/ϋ:6b $Vm'6&KlF3fΣ+Wc[̷\,46\5MTY;lfVK;_m2ЗEȵԨ' [S?+..r„Ʀnzww16`]fhRT}FS譝k`$d.K6^hlZҹcYEvkbVEA;=A `ێ?i{76Wk[XF.MYbnrn{ּ [vK/ F9WQvBЎ Uv`bl蚗6&Gg7v cMMӕCl6r ڦ㢾jdfml9bk}7Y-ZC:6h#C41m >>`mMY]]5ty-^1BXf1 [ >a 6{|p Xqּhw׆ڐpX 6=qBij뵲6gѭn0llm컵fε5lҧ1h#X`Q>`[0wԶ=6К~/=eFfcԳ,ah]f bZuw[sK.2۵17v,Xx$ϳQok \_c u:X/+CbX$ֆ6jE7xRm4hgm-m}ƛYk(j`m{c(6hh_,WTL>-6hVjSCnҥbKmǰc(c86Q!Sɨ7SlSckJM>`Wf[rT ;zZ\Q^Ew`IMƸOŬupfJ6v,nmņ5JRg > V{kThIMwĚ7q-^ Oe6.J6 ߟ(LLriincl3qrfdXŠ-:f+WdTP|-^%e5LE'dmbn[%6;6nKoHϢbrLذ{\Fu`3ekS*u6 mv{+~MÆ|FlWF\!l:_?|/듚ZC(MhV1blBvqhJԃs؈Zdn♲>}_~R.UMRnWI9kdAjG'ؖԔ+` <|?g߰5m9+su3Ԉ *>(RcZS,׀گ=A1Y}99l%5#lqEn͎,c;~o‹O_)Tkd#lu6"/uBnNBl ɋ6t0v?ּNFٳht?˷^&J6mFdg'm4֋Ew'nB`Ï$F\A?uvsC`yE>1@[Di>kkO JaeVMlpϿ~T{sC= kDnIԜpaP aGdQ3'ilN6Q=94*[]$=ÒE\Вx5j!v$ɬ ~|ZG<(YjM\+A~ϞZk=Ij[?P֯_^Pذ<6cyȂ )kP(d{_⟟Oun}Lw6XXdL&g^&.}kp?F}GM-QSgca?ſp"}nDke- 3[Khlp~`Ît7$46?ras`mQ-s> cmn??7<_d 5LΚZlį l2ʧͻ)+%/|u-۷߽>e?Cjf- PP^C x+孝=< )n39Rl/XsIDATY4X\R(k_)j?O?(D&}[fOtC)FYӷiFbÏSaO9ln3]EP DP&}Ǐ>OV+kpY>uk5x)y`(k*Xk{ǿ4jrWkVGA Q`Xlu*~k̚|KX<Ԃ [fx2G]cR[ z6t͚1 St?p&7cKuE,i%5/xϚ;%-]AnDQ"lJcg/l kU_uWD_&N+ZZ[{s;FFZñQ< Mkd)np߯f2R}pz`?kͬweyL-ՠ XGxcKW45[! D/_558Kj\dV3k%FGYZW;]`FO9lJM^Ƣ_Қ\{}/o T_Y}̗ZI\ k~Z6z16sĮ Y M5hθCmz uj}՝]=7? LikGw-A hmԖYMGcCVT×`Kj>kl5khu¬XCE&`r7yru40K!6lšw ;V!NAlxckQ S$n [ve4آhk7 H˵V\jޫ~ZC6Soa$v&+ز&%ز+ަ16|К`|rɒ-iݻ;]4KxXN7v2\.;[[Zphc5Q=,߶OQ*|}R[S=3:Zڈ\5N߁&ֆղeYlݖFu6x'Q"j}SJ?4Q}%>SքYK^5$tuj+=ʗXFPv[Z}mkaR{Q)SWkR(Zk:#oDXe UºcM~C TLwxcktnqq5fxUv^!l%5a-kD{2.WR20ֆ?JW梭RAkS*O:[kTij0k]`['Ubj[fٙ `,3$\[A}]kUJ To^⍭=6q p&! ׫Xk#9~dZ]5s) ]=^%ۻ?ͶJ T3>uZIzmlz>n-y{dO%Q_}{Y*7Py{ްm2 s˜*Cm]`+l%I@zdV)7Sz rUKmk^kSi77.2l-L˼ڷZ^{ز7dRa1k'ƃ9*@5S_('^[K6iJ2nZD-..:-5 C0#sPsRvMx T٫W/k@mϭ% XciJv`Ys3Ef%0ORڞWRV^&o~gM}}"]! WIE|hk꺉hcC!73[&jCA-9x;]+nEE dRv?Xmu-u&Nv-oec^l.rP%M nd 0}R+8t݀"l4xT!-2#gMlq 7om n-dњnoLZ+Gm(e[Zx}wkur@Sm n-d$藵aFP+8Ά6T+HuMæOba32ukNb Λjҏ(5Ya NJLGPiΚo-݃ aҦ,K6[-M^z~ZBZ>5Ӫ`ϣkh,PA" &t=QYCxFf+58q˗|d .TQwȬ*(Ćl%OMkZG:.k9Ӄ\bY/^n/e ..4E%凙BB׹68h4&-JClͳgW/tzaՆAZKB ݪMhXj4)e ÆQ[G:֘?߾Éw6s~tϘCvܭ=,ڢeN!nl TZilŃ*5H5q&^X_2MI;Pkf-\y.΍Bi\fcSwfֆ5/D&i dj:jCȫU{E[dnG)l\&o31lP^C'Кӗ_|+fUr u5yjmmr0@d-eK3\s85XՕ~5XAk'Q o6S{T;ioMNc%UT)BMbmԖm67֦DcCkbO/umIjuSs֬6Z_X7cN Rj 6 jEMp4]x7wĶXxPQX3|kuP?ӓv6ڕؼ|2 }{muvUhis˩X#bikQDcwOHsnoui͟cѧP^uTKjGbMi[Rz֒*KCPJ9MoQ PlzЍzoq`>{(fѵr5S%-&=9lQȈ-Mh:X] HPCmv!={ȴ57#wv6}w^Qj~H`!8>kݦf& a(ټ!ޤ+X1k}ís$ֺ=U 9FĦ,Hj 9IM\i(z+qX;5zFyBZmkrT6Zm5PgX.c -$&9 kVld 7B>fN,Vz9jA7=,f)jׁ4F9k`o׷M}zk5Z" Y3ݑM$?`/P- [qXؼʛ %' s` ɪձHwuBZ-㛽v4NN3OZc#>{T5d%bk*ĆPlyAiX3h(mj.G`-bSn$9]15ׅ>i 9)"ۧ'8%#_ Tr[CK+[cR64.8d_abRIE#Dti͓So1 R ٧6V/v5=}ZL&lu]RY3U[bͣfK2W>5U}v$֚KJ U? IML={Ϡz$5kvnŽ'wܹ^:g -I8blԁ3``ּhk,9,fl`GeO;fuu>AP>֊u&XqX؆{]>XZCnDID-IdT{#̠9(Vbj }=AY˕'i7|^2[Pcˮ@avZ\$ ~hk*/ (r@&,ؚzP{7a̞=D6F9l)t<[}+krK~ʁXpaP}Y<:z9 k]֚iWȓhO5ݖ0a+Vb\C0 k4һͤe&8fiGc-305-mO*1X3Cql +[dmvƚO{ItB=rLL*o-fkض15v@$CClVahr cdRlqumP:E&Gث#aX3Ϝ$֐H/v:5ö ֎=aXk,ɓhH= i \ʻY3wa59wmcbj*bͯK'ENe35C5S Z4ITm;yar05sڌG̙yѼm7Y(P:ca27v댵#G!&G)kOp4# '؝&-3q<hlOĚ59`k S}$5sjԻ=+n'f4lm֞0jƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU5NUak8Uq [TƩ*lSU}(|rIENDB``!WS#YXv8[V,Mq rwpP# x[o咴(`m)D1m#2JaVEZb,Җ֥9TzS{(o./ 9`_  :oggސKj;%Pv̛YH!g |8yЯookZ ԞC t,~ghx$G?76Iy5Fe+ǼOxy:. [ޅO;7*=_k/k% ?wOW)?8`>GYR>~ e|6#wff/Lgler{_&;_J4>e,er{ĭZ?MߛY߱{W1[~9EL~[B¾qeݠ=Q?:F*}p^fJ~1`dڻd4ȿR1 &q;8I L'-Sj}P 2C6cz*KS?rիFe;yfnRS< d3$`||3,Je8>`/N/ve2y1yELMG:X}_vS`}:A?9I?n_C^(bx|gOUqҌ ۇc49f춙Z<T PCo_3/ޑݪkj-^׮*"+ wgW#h^;<<ۏGg S5E|ǣ7TqWq0Ux\~^yطCwn_$?Je~zO uw之?ɼK8r3**4,CS#xU>>UW>h# | zD5HB<\CᘨAIU>8gB|=MU><&*pLWOzM8&ϧ(\`KK.NNA-2dl 6y/i3|F`aџ'`FqEv,{4ng_jFv>UP},7Zm-/{$}v)k!ngO=[wzQl~ 2_A@%bV mp%mNݠ<CᘘQy]-E| zUΫjر*WЫ"}8&* "жEU{b=03"aڮfbc+ >K6Yo~X)2zb3b`,ku~չyS&X0s(-o&\SM^S_s>/O_kr)Ihki(SGN$l$xXS+xiqkZ< o^K̳g&c%I-XkzfiRKy[bQ 6y44oYF[MdOV yOx(I23e}F~wo L۲[]si'ΙsREQ^O Ja'G9f\gjd Pz<ۇcbJQ-E| zJ11rGۨ |p=ᘨ\6%UQ7*Y|Hgۇa• ج><~ĹCuHgC~ b@ sٍ3UP4cPj&=gN@9GFSciƣjNq4}762e0Gv%m`Ts⽿At[kyOT͌Bu?ibFoʍxR忓 jA?| ?aF 5eٶ٩W nnqFzGW~MJіYPO(*)zPǝU#@Ɏ[oxq$^kOJK;m/iQ?vrҿm_TяZ:ME3(̼>EI5R\3ze@]}%g +Q)3GQ dG_(J\Qfe}%yI=:=TѤE\8I=:=pVEzuzf# ߦUݲ`ԣ'}Msu;*Ґ Gi=.ޔ<Ɏ%3Mq$;J 8@Vz4%֛Dv.qrV}%'r*5PKNOVهz\rzr > p)wkuwɜ-$yewOo{$ۗ=^_ufՆ98WfCV i#=y}%9g +Q);{ Wbq׳3za2sȎS rszqz"sRsszqzr15*79 p*;י;s>C=Pþdz nt82zdk>W҉fTnANimlk܂X/0ɎC'3[У*+1t8Y=:ޜL'Љ㔳H'\8ztrzr /:?"oWx'!mԼ"ּ˃5LAx 9ՏRWYS;pz/JJqT魴 }?WbVu3 BNoUgT`UGzy}?WbqZ/]+e\za:<(t#ZZ\|(  wwwwwwwwzaa֑yhp~(  wwza?c8eZ% ( wwza̿e!W( *zak]c$'( *DDza˸7j~s ( wwwwwwwwza`;ͮ!LPu@( wwwwwwwwzaT-2?ք(:}ƹ( zaU i֎ކa0=( wwzawPAyc(  x$B za=5K(H%{( za- A1?VYC( 3zamBB Q( 3x$B za[-;Y`?zWL( wwwwwwwwza#37[#M( Uwwza(,H( wwwwwwwwza6)V)H)i6&( zaDP = BoT( zafH[]X,'N( x$B zaykcT?" dd@,|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> $(    6 P  T Click to edit Master title style! !  0   RClick to edit Master text styles Second level Third level Fourth level Fifth level!     S  0 ``  X*  0 `   Z*  0 `   Z*H  0޽h ? ̙33 $Blank Presentation 0 zr$ ( " $ $ 0< P    P*   $ 0(6     R*  d $ c $ ?   $ 0I  @  RClick to edit Master text styles Second level Third level Fourth level Fifth level!     S $ 6`V `P   P*   $ 6@ `   R*  H $ 0޽h ? ̙33  0'(  l  C _3  3 l  C +3  3 l  C 3p   3   0, 3BDC 2B  s *33޽h ? "  ҍʍ<(  <x < c $;` ` @ ; x < c $h;` p @ ;  F  0  < < 0 `" < 03fI`" < 02`" < 0Z3f{`" < 0Z`"  < 0  "  < <|;   < r  < 0D;0 m   <Zap 702  < 0 ;m  SfynR  < 0;̙  SlckZ2 < s *̙ f Z2 < s *̙ f  <  B8C`DEF5%8$ 0@X`@   7 D <  B8C`DEF5%( 008@4P0`@  7 m D <  B8CDEF5%8$x`H@   D7  <  B8CDEF5%(x0`8H4$0@  7 Dm Z2 < s *̙ 0 Z2 < s *̙ 0  <  B8C`DEF5%8$ 0@X`@    D <  B8C`DEF5%( 008@4P0`@   8 D <  B8CDEF5%8$x`H@   D  <  B8CDEF5%(x0`8H4$0@   D8 Z2 < s *̙m  Z2 < s *̙m   <  B8C`DEF5%8$ 0@X`@  f  D <  B8C`DEF5%( 008@4P0`@    D <  B8CDEF5%8$x`H@  f D  <  B8CDEF5%(x0`8H4$0@   D Z2  < s *̙(  Z2 !< s *̙(   "<  B8C`DEF5%8$ 0@X`@   W D #<  B8C`DEF5%( 008@4P0`@  W  D $<  B8CDEF5%8$x`H@   DW  %<  B8CDEF5%(x0`8H4$0@  W D  &<  B8C`DEF5%( 008@4P0`@  D '<  B8CDEF5%(x0`8H4$0@  DZ2 (< s *̙)Z2 )< s *̙) *<  B8C`DEF5%8$ 0@X`@  D +<  B8C`DEF5%( 008@4P0`@  0D ,<  B8CDEF5%8$x`H@  D -<  B8CDEF5%(x0`8H4$0@  D0Z2 .< s *̙Z2 /< s *̙ 0<  B8C`DEF5%8$ 0@X`@  D 1<  B8C`DEF5%( 008@4P0`@  D 2<  B8CDEF5%8$x`H@  D 3<  B8CDEF5%(x0`8H4$0@  DZ2 4< s *̙fZ2 5< s *̙f 6<  B8C`DEF5%8$ 0@X`@  6D 7<  B8C`DEF5%( 008@4P0`@  6mD 8<  B8CDEF5%8$x`H@  D6 9<  B8CDEF5%(x0`8H4$0@  6DmZ2 :< s *̙mZ2 ;< s *̙m <<  B8C`DEF5%8$ 0@X`@  fD =<  B8C`DEF5%( 008@4P0`@  D ><  B8CDEF5%8$x`H@  fD ?<  B8CDEF5%(x0`8H4$0@  D @< <;P  - :  A< <;\@C Eg(# B< <0;`\C Ee(# C< <o3i > Ez(#`" D< 03fehZ E< s *3fJhj`" F< 03fe`" G< 0ff3cLf`" H< 0ff2Kc I< s *t37 dVbD J< s *y33?& bVaB K< s *}3 dCbD L< s *33 bCaBZ M< s *ffhjZ2 N< s *̙<Z2 O< s *̙< P<  B8C`DEF5%8$ 0@X`@   D Q<  B8C`DEF5%( 008@4P0`@   CD R<  B8CDEF5%8$x`H@  D  S<  B8CDEF5%(x0`8H4$0@   DCZ2 T< s *̙$Z2 U< s *̙$ V<  B8C`DEF5%8$ 0@X`@  D W<  B8C`DEF5%( 008@4P0`@  +D X<  B8CDEF5%8$x`H@  D Y<  B8CDEF5%(x0`8H4$0@  D+Z2 Z< s *̙sZ2 [< s *̙s \<  B8C`DEF5%8$ 0@X`@  DD ]<  B8C`DEF5%( 008@4P0`@  D{D ^<  B8CDEF5%8$x`H@  DD _<  B8CDEF5%(x0`8H4$0@  DD{vT  e   `<#   T @ 0 `  a<# G Z b< s *@  Z c< s *@ ` Z d< s * 0 Z e< s * 0 ` ` f< 0*3f` g< 0*~D` h< 0*̙3 ` i< 0*S` j< 0;̙` k< 0;q` l< 0;3f` m< 0;tx n< <k33Fa CCH1$  o< <ؿ; CCH2$  p< <$;s   CCH3$  q< <<;s CCH2$  r< <;   CCH3$  s< <;P;k CCH1$  t< <;0K BCL$  u< <;&A BCL$  v< <; vN BVL$  w< <;7 e  BVL$  x< < ; BVH$  y< <h;/ BVH$  z< <H;0\C Ee(# {< < ;\C Ed(# |< <p; L  Ez(#rb }<B BG HIlrb ~< BGHINNlZ < s * Z < s * T  {  <# ,  Z2 < s *̙Q z{ Z2 < s *̙ z  <  B8C`DEF5%8$ 0@X`@    G  <  B8C`DEF5%( 008@4P0`@  G   <  B8CDEF5%8$x`H@    GQ  <  B8CDEF5%(x0`8H4$0@  G Q Z2 < s *̙qQ { Z2 < s *̙q   <  B8C`DEF5%8$ 0@X`@  i   <  B8C`DEF5%( 008@4P0`@     <  B8CDEF5%8$x`H@  i Q  <  B8CDEF5%(x0`8H4$0@   Q Z2 < s *̙Q { Z2 < s *̙   <  B8C`DEF5%8$ 0@X`@     <  B8C`DEF5%( 008@4P0`@     <  B8CDEF5%8$x`H@   Q  <  B8CDEF5%(x0`8H4$0@   Q  T dp  <#  Z < s *J0 p Z < s *` @ `B < 0D J Z2 < s *̙Q T{ Z2 < s *̙ T  <  B8C`DEF5%8$ 0@X`@   !  <  B8C`DEF5%( 008@4P0`@  ! ]  <  B8CDEF5%8$x`H@   !Q  <  B8CDEF5%(x0`8H4$0@  ! ]Q Z2 < s *̙KQ { Z2 < s *̙K   <  B8C`DEF5%8$ 0@X`@  C ~  <  B8C`DEF5%( 008@4P0`@  ~   <  B8CDEF5%8$x`H@  C ~Q  <  B8CDEF5%(x0`8H4$0@  ~ Q  < <?d8  Iga/Igb@$Z < s * Z < s *_ `B < 0D_   < <?[`  Iga/Igb@$T  {  <# ,  Z2 < s *̙Q z{ Z2 < s *̙ z  <  B8C`DEF5%8$ 0@X`@    G  <  B8C`DEF5%( 008@4P0`@  G   <  B8CDEF5%8$x`H@    GQ  <  B8CDEF5%(x0`8H4$0@  G Q Z2 < s *̙qQ { Z2 < s *̙q   <  B8C`DEF5%8$ 0@X`@  i   <  B8C`DEF5%( 008@4P0`@     <  B8CDEF5%8$x`H@  i Q  <  B8CDEF5%(x0`8H4$0@   Q Z2 < s *̙Q { Z2 < s *̙   <  B8C`DEF5%8$ 0@X`@     <  B8C`DEF5%( 008@4P0`@     <  B8CDEF5%8$x`H@   Q  <  B8CDEF5%(x0`8H4$0@   Q  < <$?c e  kBlk, Fyn or Lyn $XB < 0D   < <?0_Pw V$B and T Lymphocyte Antigen Receptors%% < B? 3BDC 2H < 0޽h ?/@b<m<}<d<g<~< ̙33  A9(  r  S $&? P  ? r  S &?  ?   B`(? 1? 9BDC(2B  s *33޽h ? a   (  XB  08c?``  Bl2? 1?  =Human Leukocyte Antigen human MHC cell-surface proteins important in self vs. nonself distinction present peptide antigens to T cellsn(2      u &N    1    N;? 1?]e  mCLASS I: A,B,C.      NHm3 1?\  sCLASS II: DR,DQ,DP0      TXA? 1?`0  ?   BxB? 1?` JJ. Noble& (2,B  s *33޽h ? r  "66H(  H H <I?\ n.The Human Leukocyte Antigen Complex (6p21.31)$/.F e H axB H HDo Z H s *` Z H s *i Z H s *P Z H s *f Z  H s *P  Z  H s *̙ 7 Z  H s * Z  H s * Z  H s *fG  Z H s *fg`  H <$?]# xBDP DQ DR B C A?`B H 0D`B H 0D` `B H 0D` `  H <U?<: Class II (1.1 Mb):  `B H 0D` q` `B H 0D0 q0  H <x\?0 y  E Class III `B H 0D0 0 `B H 0D0 `B H 0D H <`? <: YClass I (2.2Mb),  H <f?]  * XComplement and Cytokines " H <j?}   "Class I-like genes and pseudogenes #" `B H 0Dw ~ `B HB 0D ~  H <o?@Q   SFrequent Recombination fB  H 6D  !H <tt?K " e R Recombination is Rare `B "H 0D C b `B #H 0D`B `a `B $H 0D b `b fB %H 6D  Z &H s * 'H <4z?  Y Telomere "    (H <~?0   [ Centromere "   fB )H 6D r R `B *H 0DC b `B +H 0DpB pa fB ,H 6D   -H <x?+" e R Recombination is Rare `B .H 0DP pP  /H <D?j Y 6 9(0.7Mb)`B 0H 0D` p0 pZ 1H s *  fB 2HB 6Dop fB 3HB 6Dop@ fB 4HB 6Dop fB 5HB 6Dop@  6H B? 3BDC 2H H 0޽h ? ̙33 ph@@(  @&F  @  Z2 @ s *̙`  Z2 @ s *̙`p   @  B8C`DEF5%8$ 0@X`@  X 0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@  X0   @  B8CDEF5%(x0`8H4$0@  0  Z2  @ s *̙ X Z2  @ s *̙p X   @  B8C`DEF5%8$ 0@X`@   (0   @  B8C`DEF5%( 008@4P0`@  ( `0   @  B8CDEF5%8$x`H@  0 (  @  B8CDEF5%(x0`8H4$0@  (0 ` Z2 @ s *̙0  Z2 @ s *̙0p   @  B8C`DEF5%8$ 0@X`@  ( `0  @  B8C`DEF5%( 008@4P0`@  ` 0  @  B8CDEF5%8$x`H@  (0 `  @  B8CDEF5%(x0`8H4$0@  `0  Z2 @ s *̙ ( Z2 @ s *̙p (  @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@   00  @  B8CDEF5%8$x`H@  0   @  B8CDEF5%(x0`8H4$0@  0 0 Z2 @ s *̙ P Z2 @ s *̙p P  @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@    X0  @  B8CDEF5%8$x`H@  0    @  B8CDEF5%(x0`8H4$0@   0 X Z2 !@ s *̙  Z2 "@ s *̙p   #@  B8C`DEF5%8$ 0@X`@   0  $@  B8C`DEF5%( 008@4P0`@   0  %@  B8CDEF5%8$x`H@  0   &@  B8CDEF5%(x0`8H4$0@  0  Z2 '@ s *̙  Z2 (@ s *̙p   )@  B8C`DEF5%8$ 0@X`@   0  *@  B8C`DEF5%( 008@4P0`@   (0  +@  B8CDEF5%8$x`H@  0   ,@  B8CDEF5%(x0`8H4$0@  0 ( Z2 -@ s *̙X  Z2 .@ s *̙Xp   /@  B8C`DEF5%8$ 0@X`@  P 0  0@  B8C`DEF5%( 008@4P0`@   0  1@  B8CDEF5%8$x`H@  P0   2@  B8CDEF5%(x0`8H4$0@  0  Z2 3@ s *̙X  Z2 4@ s *̙Xp   5@  B8C`DEF5%8$ 0@X`@  P 0  6@  B8C`DEF5%( 008@4P0`@   0  7@  B8CDEF5%8$x`H@  P0   8@  B8CDEF5%(x0`8H4$0@  0  Z2 9@ s *̙ P Z2 :@ s *̙p P  ;@  B8C`DEF5%8$ 0@X`@   0  <@  B8C`DEF5%( 008@4P0`@    X0  =@  B8CDEF5%8$x`H@  0   >@  B8CDEF5%(x0`8H4$0@   0 X Z2 ?@ s *̙( Z2 @@ s *̙( p  A@  B8C`DEF5%8$ 0@X`@   X 0  B@  B8C`DEF5%( 008@4P0`@  X 0  C@  B8CDEF5%8$x`H@   0 X  D@  B8CDEF5%(x0`8H4$0@  X 0 Z2 E@ s *̙ Z2 F@ s *̙p  G@  B8C`DEF5%8$ 0@X`@   0  H@  B8C`DEF5%( 008@4P0`@   ( 0  I@  B8CDEF5%8$x`H@  0   J@  B8CDEF5%(x0`8H4$0@  0 ( Z2 K@ s *̙ H Z2 L@ s *̙ p H  M@  B8C`DEF5%8$ 0@X`@    0  N@  B8C`DEF5%( 008@4P0`@   P 0  O@  B8CDEF5%8$x`H@   0   P@  B8CDEF5%(x0`8H4$0@   0 P Z2 Q@ s *̙ Z2 R@ s *̙ p  S@  B8C`DEF5%8$ 0@X`@  x 0  T@  B8C`DEF5%( 008@4P0`@   0  U@  B8CDEF5%8$x`H@  x 0  V@  B8CDEF5%(x0`8H4$0@   0 Z2 W@ s *̙P Z2 X@ s *̙P p  Y@  B8C`DEF5%8$ 0@X`@  H 0  Z@  B8C`DEF5%( 008@4P0`@   0  [@  B8CDEF5%8$x`H@  H 0  \@  B8CDEF5%(x0`8H4$0@   0 Z2 ]@ s *̙ Z2 ^@ s *̙ p  _@  B8C`DEF5%8$ 0@X`@   0  `@  B8C`DEF5%( 008@4P0`@   ( 0  a@  B8CDEF5%8$x`H@   0  b@  B8CDEF5%(x0`8H4$0@   0 ( Z2 c@ s *̙ Z2 d@ s *̙ p  e@  B8C`DEF5%8$ 0@X`@   0  f@  B8C`DEF5%( 008@4P0`@   0  g@  B8CDEF5%8$x`H@   0  h@  B8CDEF5%(x0`8H4$0@   0 Z2 i@ s *̙( Z2 j@ s *̙( p  k@  B8C`DEF5%8$ 0@X`@   X 0  l@  B8C`DEF5%( 008@4P0`@  X 0  m@  B8CDEF5%8$x`H@   0 X  n@  B8CDEF5%(x0`8H4$0@  X 0 Z2 o@ s *̙P Z2 p@ s *̙P p  q@  B8C`DEF5%8$ 0@X`@  H 0  r@  B8C`DEF5%( 008@4P0`@   0  s@  B8CDEF5%8$x`H@  H 0  t@  B8CDEF5%(x0`8H4$0@   0 Z2 u@ s *̙ H Z2 v@ s *̙ p H  w@  B8C`DEF5%8$ 0@X`@    0  x@  B8C`DEF5%( 008@4P0`@   P 0  y@  B8CDEF5%8$x`H@   0   z@  B8CDEF5%(x0`8H4$0@   0 P Z2 {@ s *̙ Z2 |@ s *̙ p  }@  B8C`DEF5%8$ 0@X`@   P 0  ~@  B8C`DEF5%( 008@4P0`@  P 0  @  B8CDEF5%8$x`H@   0 P  @  B8CDEF5%(x0`8H4$0@  P 0 Z2 @ s *̙  Z2 @ s *̙ p   @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@   0  @  B8CDEF5%(x0`8H4$0@   0 Z2 @ s *̙X  Z2 @ s *̙Xp   @  B8C`DEF5%8$ 0@X`@  P 0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@  P0   @  B8CDEF5%(x0`8H4$0@  0  Z2 @ s *̙ P Z2 @ s *̙p P  @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@    X0  @  B8CDEF5%8$x`H@  0   @  B8CDEF5%(x0`8H4$0@   0 X Z2 @ s *̙(  Z2 @ s *̙(p   @  B8C`DEF5%8$ 0@X`@    X0  @  B8C`DEF5%( 008@4P0`@  X 0  @  B8CDEF5%8$x`H@   0 X  @  B8CDEF5%(x0`8H4$0@  X0  Z2 @ s *̙  Z2 @ s *̙p   @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@   (0  @  B8CDEF5%8$x`H@  0   @  B8CDEF5%(x0`8H4$0@  0 ( Z2 @ s *̙ H Z2 @ s *̙p H  @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@   P0  @  B8CDEF5%8$x`H@  0   @  B8CDEF5%(x0`8H4$0@  0 P Z2 @ s *̙  Z2 @ s *̙p   @  B8C`DEF5%8$ 0@X`@  x 0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@  x0   @  B8CDEF5%(x0`8H4$0@  0  Z2 @ s *̙  Z2 @ s *̙p   @  B8C`DEF5%8$ 0@X`@   0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@  0   @  B8CDEF5%(x0`8H4$0@  0  Z2 @ s *̙P  Z2 @ s *̙Pp   @  B8C`DEF5%8$ 0@X`@  H 0  @  B8C`DEF5%( 008@4P0`@   0  @  B8CDEF5%8$x`H@  H0   @  B8CDEF5%(x0`8H4$0@  0  ZB @ s *P@  ZB @ s *(@  Z @ s *3f @ `B @ 0f@ ` ` @ 0f @  @ 0н3 @  Da3& @ 0|33f @  Db2&D @  BCDELF&5%0H` PHhPh8x@P0 0H@      `H J @B  7hBCDELF&5%0H` PHhPh8x@P0 0H@      `( D @  BCDELF&3f5%0H` PHhPh8x@P0 0H@      `( J @B  7hBCDELF&f5%0H` PHhPh8x@P0 0H@      `x 0  @ < 3UY Ba1$ @ <3UbY >  @ <3P'T Ba2$ @ <3 PT Ba1$ @ <3   6a2 @ <3PT Bb1$ @ <3   6b2> @ 03@ ^Binds 8-10mers Expressed on most Nucleated cells Presents Cytosolic Proteins to CD8+ T cells:!_; ^ @ <,3h3 rBinds 13-25mers Expressed on APCs, Macs, B cells, activated T cells Presents Vesicular Proteins to CD4+ T cells:##sR @ <3] FClass I Class II4 @  BChDE4F8c @  08@ 08@8`@h @    P4 @  BChDE4F8c @  08@ 08@8`@h @    `` @ 0̙Z @ s *̙̙@ @ <D3Z uCHLA Class I and II Molecules Have a Distinct Structure and FunctionDD @ B3 3BDC 2T @ <33M޽h @ ? ̙33F  L(  LF ` L @ $lET P 0  L#  D p"N P    L  P 0 Z2 L s *̙P Z2 L s *̙P p  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%(x0`8H4$0@   0 Z2  L s *̙ Z2  L s *̙ p   L  B8C`DEF5%8$ 0@X`@   P 0   L  B8C`DEF5%( 008@4P0`@  P 0   L  B8CDEF5%8$x`H@   0 P  L  B8CDEF5%(x0`8H4$0@  P 0 Z2 L s *̙  Z2 L s *̙ p   L  B8C`DEF5%8$ 0@X`@   0  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%8$x`H@   0  L  B8CDEF5%(x0`8H4$0@   0 Z2 L s *̙X  Z2 L s *̙Xp   L  B8C`DEF5%8$ 0@X`@  P 0  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%8$x`H@  P0   L  B8CDEF5%(x0`8H4$0@  0  Z2 L s *̙ P Z2 L s *̙p P  L  B8C`DEF5%8$ 0@X`@   0  L  B8C`DEF5%( 008@4P0`@    X0  L  B8CDEF5%8$x`H@  0    L  B8CDEF5%(x0`8H4$0@   0 X Z2 !L s *̙  Z2 "L s *̙p   #L  B8C`DEF5%8$ 0@X`@   0  $L  B8CDEF5%8$x`H@  0  ZB %L s *(@  Z &L s *3f @ `B 'L 0f@ ` ` (L 0f @ D )L  BCDELF&3f5%0H` PHhPh8x@P0 0H@      `( J *LB  7hBCDELF&f5%0H` PHhPh8x@P0 0H@      `x 0  +L <?h Uv  <  ,L <?j x  >  -L <?vU  <  .L <|?   > 4 /L  BChDE4F8c @  08@ 08@8`@h @    `"N P    0L P  Z2 1L s *̙P Z2 2L s *̙P p  3L  B8C`DEF5%( 008@4P0`@   0  4L  B8CDEF5%(x0`8H4$0@   0 Z2 5L s *̙ Z2 6L s *̙ p  7L  B8C`DEF5%8$ 0@X`@   P 0  8L  B8C`DEF5%( 008@4P0`@  P 0  9L  B8CDEF5%8$x`H@   0 P  :L  B8CDEF5%(x0`8H4$0@  P 0 Z2 ;L s *̙  Z2 L  B8C`DEF5%( 008@4P0`@   0  ?L  B8CDEF5%8$x`H@   0  @L  B8CDEF5%(x0`8H4$0@   0 Z2 AL s *̙X  Z2 BL s *̙Xp   CL  B8C`DEF5%8$ 0@X`@  P 0  DL  B8C`DEF5%( 008@4P0`@   0  EL  B8CDEF5%8$x`H@  P0   FL  B8CDEF5%(x0`8H4$0@  0  Z2 GL s *̙ P Z2 HL s *̙p P  IL  B8C`DEF5%8$ 0@X`@   0  JL  B8C`DEF5%( 008@4P0`@    X0  KL  B8CDEF5%8$x`H@  0   LL  B8CDEF5%(x0`8H4$0@   0 X Z2 ML s *̙  Z2 NL s *̙p   OL  B8C`DEF5%8$ 0@X`@   0  PL  B8CDEF5%8$x`H@  0  ZB QL s *(@  Z RL s *3f @ `B SL 0f@ ` ` TL 0f @ D UL  BCDELF&3f5%0H` PHhPh8x@P0 0H@      `( J VLB  7hBCDELF&f5%0H` PHhPh8x@P0 0H@      `x 0  WL <Ա?j Uv  <  XL <X?l x  >  YL <x?U  <  ZL <?   > 4 [L  BChDE4F8c @  08@ 08@8`@h @    `"T P    \L# DZ2 ]L s *̙P Z2 ^L s *̙P p  _L  B8C`DEF5%( 008@4P0`@   0  `L  B8CDEF5%(x0`8H4$0@   0 Z2 aL s *̙ Z2 bL s *̙ p  cL  B8C`DEF5%8$ 0@X`@   P 0  dL  B8C`DEF5%( 008@4P0`@  P 0  eL  B8CDEF5%8$x`H@   0 P  fL  B8CDEF5%(x0`8H4$0@  P 0 Z2 gL s *̙  Z2 hL s *̙ p   iL  B8C`DEF5%8$ 0@X`@   0  jL  B8C`DEF5%( 008@4P0`@   0  kL  B8CDEF5%8$x`H@   0  lL  B8CDEF5%(x0`8H4$0@   0 Z2 mL s *̙X  Z2 nL s *̙Xp   oL  B8C`DEF5%8$ 0@X`@  P 0  pL  B8C`DEF5%( 008@4P0`@   0  qL  B8CDEF5%8$x`H@  P0   rL  B8CDEF5%(x0`8H4$0@  0  Z2 sL s *̙ P Z2 tL s *̙p P  uL  B8C`DEF5%8$ 0@X`@   0  vL  B8C`DEF5%( 008@4P0`@    X0  wL  B8CDEF5%8$x`H@  0   xL  B8CDEF5%(x0`8H4$0@   0 X Z2 yL s *̙  Z2 zL s *̙p   {L  B8C`DEF5%8$ 0@X`@   0  |L  B8CDEF5%8$x`H@  0  ZB }L s *(@  Z ~L s *3f @ `B L 0f@ ` ` L 0f @ D L  BCDELF&3f5%0H` PHhPh8x@P0 0H@      `( J LB  7hBCDELF&f5%0H` PHhPh8x@P0 0H@      `x 0  L <p?j Qx  <  L <?j x  >  L <?Q  <  L <,?   > 4 L  BChDE4F8c @  08@ 08@8`@h @    `"T P    L# D Z2 L s *̙P Z2 L s *̙P p  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%(x0`8H4$0@   0 Z2 L s *̙ Z2 L s *̙ p  L  B8C`DEF5%8$ 0@X`@   P 0  L  B8C`DEF5%( 008@4P0`@  P 0  L  B8CDEF5%8$x`H@   0 P  L  B8CDEF5%(x0`8H4$0@  P 0 Z2 L s *̙  Z2 L s *̙ p   L  B8C`DEF5%8$ 0@X`@   0  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%8$x`H@   0  L  B8CDEF5%(x0`8H4$0@   0 Z2 L s *̙X  Z2 L s *̙Xp   L  B8C`DEF5%8$ 0@X`@  P 0  L  B8C`DEF5%( 008@4P0`@   0  L  B8CDEF5%8$x`H@  P0   L  B8CDEF5%(x0`8H4$0@  0  Z2 L s *̙ P Z2 L s *̙p P  L  B8C`DEF5%8$ 0@X`@   0  L  B8C`DEF5%( 008@4P0`@    X0  L  B8CDEF5%8$x`H@  0   L  B8CDEF5%(x0`8H4$0@   0 X Z2 L s *̙  Z2 L s *̙p   L  B8C`DEF5%8$ 0@X`@   0  L  B8CDEF5%8$x`H@  0  ZB L s *(@  Z L s *3f @ `B L 0f@ ` ` L 0f @ D L  BCDELF&3f5%0H` PHhPh8x@P0 0H@      `( J LB  7hBCDELF&f5%0H` PHhPh8x@P0 0H@      `x 0  L <?j Sx  <  L <P?j x  >  L <p?S  <  L <?   > 4 L  BChDE4F8c @  08@ 08@8`@h @    `T p L# 3d ` L 0p` L 0 pTB L c $D T p L# ^d '` L 0p` L 0 pTB L c $D  L <h?6S  ZB L s *DWH ZB L s *DWH L 0`?A  0501 0201 .   L 0D?$ ^.0301 0302 //`B L 0D8cT00 L <? z Mcis `B L 0D8cTcc L <A  Mcis  L < A`  ADQA1 DQB1`B L 0D8cP `B L 0D8c$ $ P  L <Ae t  5trans  L < A EDQA1*0301/DQB1*0201 L <?4 EDQA1*0501/DQB1*0302 L <Af@. EDQA1*0501/DQB1*0201 L <AdP =  EDQA1*0301/DQB1*0302 L <4A- jMaternal Paternal   L 0pA G $Cis and Trans- Class II Dimerization$%$$  L B A 3BDC 2B L s *޽h ? ̙33 P (5(  ZyX (p ( HA1? ( Z5xaxa1?U  O DQB1*0402*  ( Z5xaxa1?W gBu  P Asp57b(XB ( 01?   ( Z5xaxa1?G e  P Leu56b(XB ( 01?T D  ( Z3xaxa1? Xa -chain,   ( Z5xaxa1?z J  Vb-chain,  ( B5 1?@ 9BDC(2  ( 05P ;BDC 2H ( 0޽h ? 999MMM     ,J (  ,r , S $A   A  , H'A? ` : j , B?` `d , <?` @ 0^b , 6nm` P ^b , 6,!`P  , 6Bl*AP  4CDR1 2  , 63   4CDR2 2  , 6t/A0 0  4CDR3 2  , 6t 3A ` P   4CDR3 2  , 6`6A   4CDR2 2  , 6Bl9A  4CDR1 2 , 0 `] B`2 D 0   D <HA6-  7TCR D <A -  7MHC D <жA 4 7APCZ D s * D <DAN  ; Tolerance T P` D# ` D BhC`DE(F hX0H`8`(`H` @   x`ZB DB s *DP D <APp :T Cell2 D 0A =  < ZB D s *D;=d  d ` D 0pi Z2 D s * P ZB DB s *DԔ] d d `  D 0> ] `2 !D 0 +  "D <xA:  7TCR #D <A  7MHC $D <A e   7APC %D <A@ N  ESignal 1 + Signal 2J &D BpCDEF8""p`0p0h0`Xp`hh`h@`8X08@08(0(08P`p(8H`hphh@h0hph@           ` P  'D <pA= B  6B7  (D fHBXC`DEXF*X08``X`@0 X 80@`H``P8(0(0(X0@       `P  )D BhC`DE(F hX0H`8`(`H` @   p  ZB *DB s *D   +D BhC`DE(F hX0H`8`(`H` @     ZB ,DB s *D @  -D <AP G  :T Cellx2 .D H)K>0 p  /D <xAfW } e ; cytokines  0D <t}A  \  8CD28 1D <,A6@' ]+The 2-Signal Model of Lymphocyte Activation,, 2D BA 3BDC 2B D s *33޽h ?.D % j%b%`??P%(  P P 65@' lMHC/self-peptide,    P BqCDEF0qA0A0 @` >  P BqCDEF0qI0I0 @` > F2 P S U l ` F2 P S Uwz ' F2 P S U$ P F2 P S U 0 R"  P s *G0*A1_ $  F2  P S *kU @ F2  P S *5 O ,  R2  P s *A  F2  P S *5 H ' R2 P s *A0 R" P s *G0*A1 s + R" P s *G0*A1N z 2 L" P c $G0** ? z F2 P S 4 J P R2 P s *A1 O _ R2 P s *A1 O F2 P S U HZ F2 P S UA F2 P S U UP F2 P S U+I R" P s *G)A1\0  P BPCXDEF(P((X(( @`   P BOCPDEF(O (P ( @`  F2 P S *5y U R2 P s *A  F2 P S *5I O R2 P s *AP  R"  P s *G)A1 ? R" !P s *G*A1` G F2 "P S *kU w@ F2 #P S 4 L" $P c $G0** ( \  ~ %P VBC!DEFyy`YYYI888888q8g8g!I!A!A!7!0! !88IIYY`y 7A I P q                99@Haa   !!!!!!!!!yy`YII88ppaaPPPH@!@8989I9I9Y9Y Y Y``yyyyy``Y```yy@`p  F2 &P S 4 i F2 'P S 1 + F2 (P S 1 2  )P 6005W   OCD4    *P 6P45U pMHC/Vb,    :B +P 3 1b ,P BSCoDEF* KoS* @`m?  -P 685> OCD4    .P 665   CD4+ Vbx T cellB &       /P 6A5 1  O    0P 6D5 :#\  OAPC   : 1P 6DH5p [  ,Activated autoreactive CD4+ TCR Vbx TH1 cellD-! @               2P 6dN5 w p  O    3P 6R5i   O   :B 4P 3 1n B D p  5P BoCZDEFX4oAZX4 @`@ \  6P 6HV5   TCR Vbx<    dB 7P <DԔ U  8P <[50 Z T  TCR Vbx<    dB 9P <DjJZE ^B :P 6D pdB ;P <Dfo+dB P 0`k5f Induction of CD4+ TH1 mediated autoimmunity: A paradigm for the pathogenesis of rheumatoid arthritis, multiple sclerosis and type I diabetes (2    ?P 0o50 A L. Chess 2002 2B P s *33޽h ?  p22T-(  TR2 T s *ĪUlz R2 T s *Ult} R2 T s *ĪUl R2 T s *Ul[H z T R2 T s *ĪUl`?ZR2 T s *UlR2 T s *ĪUl  R2  T s *Ula : R2  T s *ĪUlk  >L2  T c $3Ul R2  T s *ĪUl xL2  T c $3Ul *> T 6y5, hTH1 CD4+ cells*    T 6,G5 n  hTH2 CD4+ cells*    T 6}5b  }! CD8 or CD4 suppressor precursor,"! "   T 05U+  CD8 or CD4 suppressor effector*      T 6X5 Z  oActivated CD4 T cells*    T 65F e peptide/APC*      T 65w [ (  @B T C Ul1  c T BXCfDEFUl,,fX, @`f: T 652 @   T 6P5 q (Regulatory immunity CD4/CD8 interactions:) )   T 65D2 \(- )(    T 6ܤ5    \(- )(    T 65g ;The Control of Activated CD4+ T Cells by Regulatory T cells.<; <   T 65 : c Apoptosis*      T 6 58   nResting CD4 T cells*   dr T <HL,>h t Xb T 0dx Xb  T@ 0d( dB !T@ <D> r dB "T <D>p 20 dB #T <D> g 2 0  $T <85;H   IL-12/ IFN-gT     %T <5 x  dIL-40   ^B &T 6D> m db 'T <:̙o r R dB (T <D>(dB )T <D>{8 R2 *T s *ĪUl=3 R2 +T s *Ul u ,T 050 8 x*NKT cells/ CD4+CD25+ cells CD4+CD25- cells++ +  dB -T <D>e e  .T <5 w l  R(- )    /T <05  R(- )    0T <l5+  ]IL-10(    1T <45  oIFN-g:    2T 0x5p A L. Chess 2002 2B T s *33޽h ? 7 77\\X:7(  X6 X 05@ T cell activation is regulated by signals derived from the TCR /CD3/CD4 complex and the CD40L and CD28/CTLA-4 co-stimulatory molecules     X 65B*Z( Y &  T4L @0  X# 0 T" X c $G0*UD[p " T" X c $G0*UD[p9Z2 X s *A1 IZ2 X s *A1o    X 3 BC DEFA1   @` @ T"  X c $GF*   N2  X S *5a N2  X S *5J:i N2  X S *5 JJ N2 X S *5iq Z" X s *G0*A1PZ" X s *G0*A1YZ" X s *G0*A1/HHZ" X s *G0*A1H9HZ" X s *G0*A 1g H HZ" X s *G0*A 1 HxHZ" X s *G0*A 1`HH X 65  o Yg(    X 65e Ye(    X 65Ze Yd(    X 6|5P] Yz(    X 6D5] Yz(    X 68M [CD3(    X 68zv #  d MHC class II(      X 08'W   a,b TCRN    N2 X S *1  N2 X S *U1  BB  X 3 ]Y h  !X BCzDEF=*z= @`b$  `" "X 0G0*A  iap`" #X 0G0*A  ap $X 68o Yh(    %X 68!io Yh(    &X 68`v #  iPeptide antigen*    'X BCHDEF1HH @i P  (X BC/DEF1// @  )X 08 0 q CD4+ T Cell6     *X 6(!8i z ' [ (   +X 6P%8g `\  uAntigen Presenting Cell (APC)(    ,X 6l)8@U {  YV(     -X 64-8{[   Ya(     .X 608 U E  YV(     /X 648C[ s  Yb(     0X 688  YC(     1X 6T<8%  Ya(     2X 6@8  YC(     3X 6C8  Yb(    Z2 4X s *A U Z2 5X s *A U0  Q Z2 6X s *A Uo I a Z2 7X s *A U H T" 8X c $G0*  1P  Z2 9X s *A     :X 6X 6L8 r vAntigen specific TCR signals*    ?X BgCDEF$1g0gW`@@ yZ2 @X s *A 1 Z" AX s *G0*A1  Z2 BX s *A 1w @ x Z" CX s *G0*A1  HZ2 DX s *A 1  Z" EX s *G0*A1/  Z2 FX s *A 1 _ BB GX 3 *D[  HX 6S8 S  ^CD40*    IX 6X8   _CD40L*    JXB BCDEF$1Oo`I@w  KX BjCDEF$1j:j!X`A @   LX 6\8 B  ^signal(    N !X  MX @E N2 NX S f1 X N2 OX S f1p!(  PX 0la8  f CD28/ CTLA-4*      QX BCDEF$1Oo`I@0N  @8 RX u Z" SX s *ZG0*f3f1 ` 8Z TX s *f3f @  UX <f8@@ rCD80 (B7.1)/ CD86 (B7.2)*    VX <k8 0  _lck*   WX <o8  pCo-stimulatory signals*    XX <s8Z` b (- ) / [+](     f YXB 6o0`  ZX <w8&E0 Q[+]   lB [X <DԔ   \X 0|80 A L. Chess 2002 2B X s *33޽h ? iA AAtt\@(  \L" \ c $G)UD[ U L2 \ c $A1  L2 \ c $A1 {  \ # B CDEF1  @`   L" \ c $G%* p  L" \ c $Gx*UD[UU@F2 \ S *5 F2  \ S *5 % F2  \ S *5 r F2  \ S *5 R"  \ s *G0*A1C R"  \ s *G0*A1 bL r  \# \ N2 \ S U` r N2 \ S U@ Z" \ s *G0*A1R" \ s *G0*A1  { )R" \ s *G0*A1 m )R" \ s *G0*A 1 W)R" \ s *G0*A 1  )R" \ s *G0*A 1 ] )F2 \ S UzC R2 \ s *A  " R2 \ s *AW R" \ s *G0*A1g  \ 68l/ ]g,    \ 68' U F ]e,    \ 6|8? ]d,    \ 6T8  2  UV$     \ 68 ' X   Ua$      \ 68; h *  UC$     !\ 6t8m ?  Ua$     "\ 68 *  UC$     #\ 6ĭ8  ?  Ub$     $\ 6ܱ8e $  UV$     %\ 68~ ' R  Ub$     &\ 68; o  ]z,    '\ 68  ]z,   R2 (\ s *A U  R2 )\ s *A U dJj R2 *\ s *A U {r R2 +\ s *A UjJ% L" ,\ c $G0*  1 R2 -\ s *A   .\ 68s sp56 lck.       /\ 6P8  ` ,    0\ 68/Bs _ ,    1\ 6X8h |  _ ,    2\ 6 8k   cpeptide,    3\ 68;   aCD3.    4\ 684Uj bCD28.    5\ 6x8 "z bCD40.    6\ 6@8 + l  cLFA-3.    7\ 68a  cLFA-1.    8\ 68O   dICAM-1.    9\ 68@ U  dMHC II.   L !   :\#  \HN2 ;\ S UU!  `" <\ 0G0*AU1 I   =\ 68   PB7    >\ 6t8p  cCD40L.    ?\ 6<8@   aCD4.    @\ 6: +  bCD45.    A\ 6: :  aTCR.    B\ 6:6 aCD2.    C\ 3 BC9DEFA 1Iy99I @` J  D\ # BCDEFU1Xw @`m%B E\ 3 BCDEFA 1? @`* F2 F\ S U1 {_b F2 G\ S U u" R" H\ s *G*A1 3  I\ 6:P J g CD4+ T Cell,      J\ 6: U2  g APC/ B cell,     X" K\ 0G0*A1R X" L\ 0G0*A1{<y L" M\ c $G0**1 N\ B/CDEF/ @`9   O\ B7CDEFU7 @`9  F2 P\ S *1 ] F2 Q\ S *U1) d X" R\ 0G0*A1y Wi R2 S\ s *A 1I  :B T\ 3 D[ UW L   U\#  Z2 V\ s *A 1*2  Z2 W\ s *A 1 " Z2 X\ s *A 1B  Z" Y\ s *G0*A1R9 X" Z\ 0G0*A  1 P YX" [\ 0G0*A  1: Y \\ 6p: < F ]h,    ]\ 6p :| F ]h,    ^\ 6l$:K 0Molecular Interactions of Helper T Cells and APC,10 1  ^B _\ 6D+R `\ s *PPM L 0  a\# `# Z b\ s *PP ' Zb c\ s *PP0L !   d\#  # N2 e\ S UU!  `" f\ 0G0*AU1 I   g\ <*: UM  PB7    h\ <8.:UPt TCTLA-4   dB i\ <DԔ p dB j\ <DԔP L" k\ c $G0*f10 L" l\ c $G0*31 U  m\ <1:` 4  ]VLA-1(   L @ @  n\# e r 2 o\ # BCDEdF,>#Hk+z2GKOC@&++WHokfrv|@        @ U 2 p\ # BCDEdF,>#Hk+z2GKOC@&++WHokfrv|@        U  2 q\ # BCDEdF,>#Hk+z2GKOC@&++WHokfrv|@         @  r\ <7: t  `Collagen(     s\ <<: K g CD80/CD86.      t\ 0@: A L. Chess 2002 2B \ s *33޽h ? =? >>qq`>(  `lL   `A#  `  BCDEF1A@A@A @`jdT" ` c $G0*f ! `  ^BC/DEF ~~vgggPP>y>y/yXXXXXIII~IoIVINI?XX *PqNo~Pgv'6Wfw`~  /q/a/A/*// y~Xo:7(((((:wIwXfyfWWWG6''@  N2 ` S 4!> ` 0I: i MHC/peptide.  f   L I  ~ `A# +N2  ` S *kUoI  ~N2  ` S 4o }   `@ BCDEF9G9G9 @`B  `@ ByCDEF9yG9G9 @`EF2  `@ S *5/gR2 `@ s *A _F2 `@ S *53R2 `@ s *A F" `@ S G0*31WKF" `@ S G0*31SjB ` Btj&DfԔ ` 6O:0  aTCR.f    ` <U:0 + :   Qa-1/Vb@ff(      F2 ` S o F2 ` S 4`3   ` BCDEF9G9G9 @`C  ` ByCDEF9yG9G9 @`C F2 ` S *5/= R2 ` s *A< F2 ` S *5B KR2 ` s *A CF" ` S G0*317\ zF" ` S G0*31 Z I  ` 0l]:+  vActivated CD4+ T cell0f    !` 6$b: f  F  L  r U "`# @U * # T2 #` c $IUU1 r T2 $` c $IU1  Z" %` s *IG0*3] J BZ" &` s *IG0*U}]  U '` <`B 0}A3o  Z" ?`B s *}G0*33o A  f" @`B 6}G0*A3o< s  A` <`:    Activated CD8+ T cell>f   ^r B`@ 6r++ ` ^r C` 6+` + Xr D` 0}"3+ dB E` <Dfo +  dB F` <Dfo U   G` 0:U  _(+), 2f    H` 0,: U  ](-)* 2f    I` 6H:+2- aTCR.f     J` 0|:  ]APC* 2f   dB K` <DfԔP 3PL Pp L`#  + Z2 M` s *A 1z>Z2 N` s *A 1-&Z2 O` s *A 1PpZ" P` s *G0*A1  Q` 6:`  aTCR.f   F2 R` S o0,F2 S` S 4 T` BCDEF9G9G9 @`s= U` ByCDEF9yG9G9 @`sBF2 V` S *5_+R2 W` s *Al|F2 X` S *5/{R2 Y` s *AsF" Z` S G0*31gSF" [` S G0*319Oy \` 0:3 {Late Activated CD4+ T cell0f    L P@  ]`# p T" ^` c $G0*f1P T" _` c $G0*31@  `` <l:   _VLA-1*f   L @ @  a`#   2 b` # BCDEdF,Ԕ#Hk+z2GKOC@&++WHokfrv|@        @ U 2 c` # BCDEdF,Ԕ#Hk+z2GKOC@&++WHokfrv|@        U  2 d` # BCDEdF,Ԕ#Hk+z2GKOC@&++WHokfrv|@         @  e` <:   VCollagen  f    f` <$: y aCD40L,f    g` s *ܸ: T  |"Migration of sites of inflammation*#" #   h` s *L:]  (Induction and activation of B cells APCs ))$    L  r U i`# jA|T2 j` c $IUU1 r T2 k` c $IU1  Z" l` s *IG0*3] J BZ" m` s *IG0*U}]  UR" n` s *G0*f1 R" o` s *G0*1K  p` <h: 4  dCD250ff    q` 0: A L. Chess 2002 2B ` s *33޽h ? t otgtdt(  d d 6T:|| D  L p v\ ; d#   9pl2 d <OkAp v\ ;H2 d C  $ L #  d#  N dZ ;  d dZ ; N2 d S U  ; N2  d S UZ N2  d S UL $ N2  d S Us Z"  d s *G)A1dsTN    d  N   d  N2 d S *5Z Z2 d s *Ak  N2 d S *5 | Z2 d s *A s Z" d s *G0*A1* \z N #  d # N2 d S *kU # N2 d S 4[E  L  _ d# >  d   BC_DEF̙lttp__W@x7g/P/??77  /7@W_p 7??Pggx8@@OWWxpxpgwgwP?7 wwphWOW?W8O8OOOWpw88Ohw   00077 77P?PPPgXxXXXPP70  07PXg 7Pgp''HOO_xpxgxPx7_ ___________g_X_P_7_0_ __xGO`w  07PXX g /77PP___g_X_PP7P0P 77/// wwppWWWWwW`WOWGW(WWWppppwwwpxWxO_OO@O8O_xxp_@G7O/O/``````OOOGGGGw(o(X(XO?((?OXow/7@W__px_OOH'@ _N2 d S  1 HL I   d# N2 d S UU1  N2 d S U1I n T" d c $G0*U]h'  T" d c $G0*U}] y L I   d# PN2  d S UU1  N2 !d S U1I n T" "d c $G0*U]h'  T" #d c $G0*U}] y  $d 0:d sActivated TH1 CD4+ T Cell*    %d <T:pd  `CD4+ Cell (TH2 )     &d 0 : 6 `CD4+ Cell (TH0 )    L #  'dA# 9 `N dZ ;  (d dZ ; N2 )d S U  ; N2 *d S UZ N2 +d S UL $ N2 ,d S Us Z" -d s *G)A1dsTN   .d  N   /d  N2 0d S *5Z Z2 1d s *Ak  N2 2d S *5 | Z2 3d s *A s Z" 4d s *G0*A1* \z N #  5d # N2 6d S *kU # N2 7d S 4[E  8d 0(: wDR3, DR4,,DQ8/insulin peptide*     dB 9d <DԔ9dB :d <DԔ dB ;d@ <DԔd4B d 6D:RR D   ?d 68: DL _CD2,    @d 6$; Macrophage/dendritic cell.&         Ad 6;p pFc R.      DL    Bd#  d`^ T   Cd#  v T2 Dd c $Ah7<B Ed # w<B Fd # }*+T2 Gd c $Am KT2 Hd c $Am rT2 Id c $A! T2 Jd c $A ><B Kd # `<B Ld # w<B Md # i<B Nd # iQR<B Od # UrT2 Pd c $A T2 Qd c $A`Y<B Rd # P*BB Sd 3 nwBB Td 3 n}*+H2 Ud C xm KH2 Vd C xm rH2 Wd C ! H2 Xd C  ><B Yd # iQRH2 Zd C Y}h H2 [d C Yui H2 \d C Y  H2 ]d C YY l N2 ^d S |BB _d 3 ShTN `/ `d `/l2 ad <OkA`/H2 bd C  H2 cd C .iBB dd 3 .P* ed 6;Z o  _ ,    fd 6;I _ ,   T   gd# ` ` Z2 hd s *f Z2 id s *f Z2 jd s *f L 3 -  kd# Z9N2 ld S U3  `" md 0G0*AU1 * - z Xb nd 0 P od <;d  IFN-g N    pd <X ;0 t SIL-12    qd <X#;X _CD40L*      rd <8%;9y= ^CD40*      sd <+;d$ ha,b, TCR0      dB td <Do9F2 ud S xxd@ vd 0/; 9   zIL-1, TNF, LT, NO, PGE-22 2   dB wd <DԔ  dB xd@ <DԔ 9 L I   yd# p0 N2 zd S UU1  N2 {d S U1I n T" |d c $G0*U]h'  T" }d c $G0*U}] y L 3 -  ~d# `  N2 d S U3  `" d 0G0*AU1 * - z zL   d# Z`  Z2 d s *f Z2 d s *f Z2 d s *f dB d@ <DԔ 9 |L   } d# 0 d) B2 d 3 5 ? 4B2 d 3 5 8? bB2 d 3 Y 8 }B2 d 3 Y  4|L   } d#  d)7 B2 d 3 5 ? 4B2 d 3 5 8? bB2 d 3 Y 8 }B2 d 3 Y  4|L   } d# P  B2 d 3 5 ? 4B2 d 3 5 8? bB2 d 3 Y 8 }B2 d 3 Y  4L @ @  d#  9 N `   d @ @ Z2 d s *`  Z2 d s * 0 N   } d  P H2 d C 5 ? 4H2 d C 5 8? bH2 d C Y 8 }H2 d C Y  4N   } d    H2 d C 5 ? 4H2 d C 5 8? bH2 d C Y 8 }H2 d C Y  4 d <|?;P c$ ^B Cell(    d 0 D;   ?anti-insulin, GAD ab anti-Mog( 4         d <pH;d \IL-4(    d <N; G@ !Immunopathophysiology of Diabetes&"!     dB d <DԔ  d <Q;0  q?Antibody mediated injury(    d <pV;Ԕ0  F   d <Y;`> qDendritic cell/ APC        d <X; Xm  SCD40L     d <`;   o IL-4 CD40L 4     dB d <DԔ d R2 d s *f R2 d s *f   d <f; B #  @   d <Xj; U  bCD8+ CTL*     d <n; l  i FasL perforin*   dB d <DԔ  0 L  p 0p d# @ 9T  @  d#   d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ` @  d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ``  4T  @  d#  pp d # B C#DEFZԔ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ` @  d # B C#DEFZԔ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ``  T  @  d#  0p d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ` @  d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ``  4T  @  d#  p 0P  d # B C#DEFZԔ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ` @  d # B C#DEFZԔ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ``  T  @  d# ` 0  d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ` @  d  B C#DEFZv2 @Ԕ:: 3:dRdaD0,-% U_;O j@;*o: : >( 6HX$#cl:T *,@                   ``  dB d <DԔ  d <v;d v b cell death: f ff   ^B d 6D> dd ^B d 6D>` ` ^B d 6D>6 6 dB d <DԔ 9  d <}; z  u b islet cells8    dB d <D>@+  d 0; A L. Chess 2002 2B d s *33޽h ?   @84=( w 4r 4 S @AP  A X 4 0 X 4 0 0  4 0LA ` c T Cell* 2   X2 4 00 `X  4 00`  4 0A@ : JCD28 2    4 0A@ : PB7 2    4 0@A P   [TCR-MHC$ 2   X2 4 0 @X2 4 0 PX2  4 0X2 !4 0@` "4 0A@ ` GLPS 2   X #4 0Pp $4 0B@0d  *Toll Like Receptor (pattern Recognition R)&+ 2 +  pB %4 HDo`0 pB .4@ HDo@`  pB /4@ HDo @ 04 0dB   v(IL-1,6,12  Signal 3     jB 24@ BD8c  jB 34@ BD8c   44 0 B @ VSignal 2 2    54 0B   VSignal 1 2    64 0B p uAnitgen Presenting Cell (APC) 2     74 0B` GBDC 2   jB 84@ BD8cB 4 s *33޽h ?   phc(  hx h c $$`   x h c $V`0   x h c $TwV`     h 0wV` KBDC 2   B h s *33޽h ?   /'`8(  8l 8 C l(B  B | 80 0A ?   B 8 0X*B  5BDC 2B 8 s *33޽h ?      0& (  02 0 6&3`  `Avidin$,,Xr 0 0_P ^r 0 6eL?Q ^r 0 6hM O ^r 0 6-O ^R 0 6 ]]= XR 0 0] ^R  0 6Z P }^R  0 6}P -X2  0 0 X2  0 0 X2  0 0  X2 0 0]  } 0 <,G3 .@ DQv 0 0hJ3 DQ 0 <|M3@p ` DQ 0 BL3  3  0 <8Q3p  DQ 0 0(T3@ 7PEPTIDE 2pB 0@ HDjJ0 @ 0 BTW3 1?`PZ 9BDC(2H 0 0޽h ? ̙33 0  ,(   ^  S $   B  c $"B$ @  B "  H  0޽h ? a( Nx[ lw><qBgs o6qKM>zr^Q"RJR)+J܆F"5* 4UVi"T1هBwv^;3;܉7 P"] ) *|yll̎s(8W!?0㐙|9h\.oRr7].*}9\\o;TOB_4RnvgNWEƟy]&l͡?<?RTkiʭ. SuyfeC|hB;tk,k}>Xs2"13xlsAFc\93}S=1RD4i5m!J< /˫ x:ЧmzZJL#Q2,{dY^~dM!G40,zpc,Ȼ9T `)4oe{7aa5AW37S6.%>7%Ñn)7]KQU{԰ qyW$GR%jh48f`#hQ=qc5$<~=oC'{EBG%hv_)0 ifu=Պ2 / ,u)1)jꌬעScjm?O RN_d6>yɐ\=ڤXgyqrCy gaFc" .\p… .uڂRfQ#H~ْJ]gvk>9Ş ` 8f'M>\kBԾc|Âљm6;3/gS=Q}͍(v5Q緟>@͚i鱱m|Y\ϩй 6gԦwy?\QmWٺ5iFg?BC&e¾,>~z:VT7_,z-Vt>>6lq<=xztSWb䱯}MP`<sU BR =`8x<||w,x s|pO~1y+RN9[J"k \ȳH,{Dvs?'\+^#;KFS1\QhȲ!=Z:q8o'\m|yc3 0 '3 GFFu'RΎ* pruh\> ]a/_BsT|xd{g$veC 1kM|Wu4m471VW!b=:'ϺO]c#DgFo3E&+N^'nGQ$W7)x9s{o̙Q7GuoYό;z]z̩_[5AsN^xjU#dYH'&yf4ɳ9rf-SYAM3Tui>gܠvV>ʽ,O.=x3]-IY4Iˮ 2ΰU0 zyz=M3].\p… .\pB6c_P-O"ɗҤ;ۺ}$m]$<{_a+=Km{lk%ɽ!UteD#dŝvv}*?GC\>2wv%]1+/ZmouJT`GKÃ͟oi׼n;(5R֣2ᮇ6PW "QHBj5Up+:օ .\p… .\p?*`[rp@E-B`'X-5 q.0SZGq e.mpsOh+'0H hp  $ 0 <HPThe Immune SystemeGeorge Eisenbarthe;C:\Program Files\MSOffice\Templates\Blank Presentation.potBDC37Microsoft PowerPointfic@p+@e@ʪGg  $& &&#TNPP2OMi & TNPP &&TNPP    33--- !---&G&rw@ I UwUw0- &Gy& --yyH-- @Times New Roman UwUw0- .!2 QThe Immune System#..!/.--IH-- @Times New Roman UwUw0- . 2 R .@Times New Roman UwUw0- .2 vInnate  .--w-- v@Times New Roman UwUw0- . 2 R . .2 v Antimicrobial     . .2 #vPeptides . . 2 YR . .2 Yv Phagocytes a  . .2 v(Macrophages, !  . . 2 ]PMNs!. . 2 , . .2 v Monocytes! . . 2 , . . 2 -DCss. . 2 p) . . 2 R . .2 v Alternative     . .!2 vComplement System   .--Iy--  . 2  .@Times New Roman UwUw0- .$2 Acquired (Adaptive)    .--]-- _@Times New Roman UwUw0- ]. 2 - . ].2 ! B Lymphocytes  . ].2 2Antibody . ]. 2 t- . ].2 t! T Lymphocytes  . ].2 1 Cytotoxicity    . ].2 1Help Antibody   . ]."2 1Cytokine Secretion     .--xH-- ]@Times New Roman UwUw0- ]. 2 RBDC.--"System 0-&TNPP &՜.+,0    DOn-screen ShowUCHSCeei Times New Roman Arial NarrowSymbolArialTimes HelveticaBlank PresentationMicrosoft Word DocumentThe Immune SystemPowerPoint PresentationCXPID: X-linked polyendocrinopathy, immune dysfunction and diarrheaHLAPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationHLA-Peptide: TCRCo-StimulationPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationPowerPoint PresentationPowerPoint Presentation;Innate Immune System: Toll-like receptor activation of APCTh1 vs. Th2 CD4 T CellsCTr: T Regulatory Cells Review: Roncarolo Curr Opinion Immunol 2000Tetramer for T Cell Analysis  Fonts UsedDesign TemplateEmbedded OLE Servers Slide TitlesRoot EntrydO)`DNRO@Pictures9ZCurrent User;SummaryInformation(6x      !"#$%&'()*+,-./012345789:;<=>?ABCDEFGVRoot EntrydO)2eYMPictures9ZCurrent UserASummaryInformation(6x      !"#$%&'()*+,-./012345789:;<=>?ABCDEFGV#_W Legend UserLegend User!_W BillgatesBillgatesser  !"#$%&'()*+,-/0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./012345789:;<=>?ABCDEFGVRoot EntrydO)06 I@Pictures9ZCurrent User(SummaryInformation(6xPowerPoint Document(.{DocumentSummaryInformation8@